- Salt N' Pepa
- Samantha Mumba
- Sara Bareilles
- Sara Evans
- Sarah Connor
- Sarah McLachlan
- Sarai
- Sarina Paris
- Sash
- Savage Garden
- Save Ferris
- Saves The Day
- Saving Abel
- Scandalus
- Scarface
- Scene 23
- S Club 7
- S Club
- S Club Juniors
- Scooter
- Scorpions
- SDoun
- Seal
- Sean Paul
- Secondhand Serenade
- Seether
- Selena
- Selwyn
- Serial Joe
- Sev
- Seven And The Sun
- Seven Channels
- Sevendust
- Shaggy
- Shakira
- Shania Twain
- Shannon Noll
- Sharissa
- Shawn Desman
- SheDaisy
- Sherrie Austin
- Sheryl Crow
- Shyne
- Silk
- Silkk The Shocker
- Simon & Garfunkel
- Simple Plan
- Sinch
- Sir Mix-A-Lot
- Sisqo
- Sister Hazel
- Sixpence None The Richer
- Skunk Anansie
- Smashing Pumpkins
- Smash Mouth
- Smile Empty Soul

- Smilez And Southstar
- Snoop Dogg
- Snot
- Snow
- Snow Patrol
- SocialBurn
- Soil
- Solange Knowles
- Soluna
- Something Corporate
- Son By Four
- Sonic Youth
- Sophie Ellis Bextor
- So Soild Crew
- soulDecision
- Soulja Boy
- Sound Garden
- South Park Mexican
- Spice Girls
- Spooks
- SR-71
- Stabbing Westward
- Stacie Orrico
- Stagga Lee
- Staind
- Starsailor
- Start Trouble
- Static-X
- Stella Soleil
- Stephen Speaks
- Steps
- Stereo Fuse
- Stereomud
- Stereophonics
- Stevie Nicks
- Stevie Wonder
- Sting
- Story Of The Year
- St. Lunatics
- Stroke 9
- Stone Temple Pilots
- Suede
- Sugababes
- Sugar Cult
- Sugar Jones
- Sugarland
- Sugar Ray
- Sunshine Anderson
- Superman Lovers
- Suzanne Palmer
- Suzanne Vega
- Svala
- Switchfoot
- Swollen Members
- SWV